Haptoglobin Type and the Development of Delayed Ischemic Neurological Deficits After Subarachnoid Hemorrhage
نویسندگان
چکیده
The Haptoglobin-Vasospasm Study Group: Northern Neurosciences, Inc.: Mark Borsody, M.D., Ph.D.*; Tamara Heaton, M.S.; Chisa Yamada, M.D. ”La Sapienza” University of Rome: Federico Bilotta, M.D., Ph.D. (Department of Anesthesiology); Andrea Doronzio, M.D. (Department of Anesthesiology); Giovanni Rosa, M.D. (Department of Anesthesiology); Antonio Santoro, M.D. (Department of Neurosurgery) Department of Pediatrics, Wayne State University, Detroit, Michigan: Dawn M. Bielawski, Ph.D. Department of Neurology, Wayne State University / The Detroit Medical Center, Detroit, Michigan: Abraham Kuruvilla, M.D. Department of Neurology, Northwestern Memorial Hospital, Chicago, Illinois: Allan Burke, M.D. Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel: Andrew Levy, M.D., Ph.D.; Rachel Miller-Lotan, Ph.D.
منابع مشابه
[Effect of external decompression on the development of delayed ischemic neurological deficits after subarachnoid hemorrhage].
The protective effect of a large decompressive craniectomy against delayed ischemic neurological deficits (DIND) was evaluated in patients operated on after subarachnoid hemorrhage due to a ruptured aneurysm. In 54 cases, a large decompressive craniectomy was performed (Group D), and 41 patients underwent conventional craniotomy (Group ND). Transient DIND appeared in three (17%) of the 18 Group...
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OBJECTIVE The effect of ebselen, a seleno-organic compound with antioxidant activity through a glutathione peroxidase-like action, on the outcome of subarachnoid hemorrhage was evaluated in a multicenter placebo-controlled double-blind clinical trial. METHODS Patients who suffered aneurysmal subarachnoid hemorrhages of Hunt and Kosnik Grades II through IV at admission and were able to start d...
متن کاملC-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage.
PURPOSE To evaluate the relationship between C reactive protein levels and clinical and radiological parameters with delayed ischemic neurological deficits and outcome after aneurysmal subarachnoid hemorrhage. METHODS One hundred adult patients with aneurismal SAH were prospectively evaluated. Besides the baseline characteristics, daily C-reactive protein levels were prospectively measured un...
متن کاملDo endothelin-receptor antagonists prevent delayed neurological deficits and poor outcomes after aneurysmal subarachnoid hemorrhage?: a meta-analysis.
BACKGROUND AND PURPOSE Delayed ischemic neurological deficits (DINDs) contribute to poor outcomes after aneurysmal subarachnoid hemorrhage (SAH). Endothelin-1 is an important mediator involved in the development of vasospasm. METHODS We performed a systematic review and meta-analysis of randomized controlled trials assessing the use of endothelin-receptor antagonists (ETRAs) in patients with ...
متن کاملDoes intracisternal thrombolysis prevent vasospasm after aneurysmal subarachnoid hemorrhage? A meta-analysis.
OBJECTIVE Despite existing strategies for the treatment of vasospasm after aneurysmal subarachnoid hemorrhage, vasospasm remains a persistent contributor to death and disability. The intracisternal application of thrombolytic agents to dissolve subarachnoid clot has been advocated. The goal of this analysis was to assess the currently available evidence regarding the effectiveness of this treat...
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